International Journal of Diabetes Mellitus
Volume 1, Issue 1 , Pages 11-15 , April 2009

Mitochondrial tRNALeu(UUR) gene mutation and maternally inherited diabetes mellitus in Pakistani population

Received 9 October 2008 ,Accepted 20 December 2008.

References 

  1. Wahid M, Naveed AK, Hussain I. Insulin and glucagon ratio in the pathophysiology of diabetic ketoacidosis and hyperosmolar hyperglycemic non-ketotic diabetes. J Coll Physicians Surg Pak. 2006;16(1):11–14
  2. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, Diabetes Car 2003;26:15–20.
  3. Murray RK, Grarmer DK, Mayes PA, et al. Harper’s biochemistry. 25th ed.. New York: McGraw-Hill; 2000;p. 610–26
  4. Zeviani M, Carelli V. Mitochondrial disorders. Curr Opin Neurol. 2003;16:585–594
  5. Luft R, Ikkos D, Palmieri G, Ernster L, Afzelius B. A case of severe hypermetabolism of non thyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study. J Clin Invest. 1962;41:1776–1804
  6. Wolf NI, Smeitink JAM. Mitochondrial disorders. Neurology. 2002;59:1402–1405
  7. Walker UA. Inherited and acquired disorders of mitochondrial DNA. Schweiz Rundsch Med Prax. 2002;91:2129–2138
  8. Brunmair B, Lest A, Staniek K, et al. Fenofibrate impairs rat mitochondrial function by inhibition of respiratory complex I. J Pharmacol Exp Ther. 2004;311:109–114
  9. Chen YN, Liou CW, Huang CC, et al. Maternally inherited diabetes and deafness (MIDD) syndrome: a clinical and molecular genetics study of a Taiwanese family. Chang Gung Med J. 2004;27:66–73
  10. Ohkubo K, Yamano A, Nagashima M, et al. Mitochondrial gene mutations in the tRNALeu(UUR) region and diabetes: prevalence and clinical phenotypes in Japan. Clin Chem (Mol Diagnost Genet). 2001;47(9):1641–1648
  11. Dods RF. In:  Kaplan LA,  Pesco AJ,  Kazmierczak SC editor. Clin Chem. vol. 31:New York: Maplevail Press; 1996;p. 634–635
  12. Morris CJOR, Morris P. Separation methods in biochemistry. London: The Pitman Press; 1976;vol. 2, p. 93–148
  13. Obesity Presenting and Managing the Global Epedimic. Report of WHO consultation on obesity, Geneva, 3–5 June 1997, Geneva. WHO, Division of non-communicable disease, Programme of Nutrition, Family and Reproductive Health; 1998.
  14. Finsterer J. Mitochondriopathies. Eur J Neurol. 2004;11:163–186
  15. Tzen CY, Thajeb P, Wu TY, et al. Melas with point mutations involving tRNALeu (A3243G) and tRNAGlu (A14693G). Muscle Nerve. 2003;28:575–581
  16. Maassen JA, ’t Hart LM, Van Essen E, et al. Mitochondrial diabetes: molecular mechanisms and clinical presentation. Diabetes. 2004;53(1):103–109
  17. Shuldiner AR, McLenithan JC. Genes and pathophysiology of type 2 diabetes mellitus: more than just the randle cycle all over again. J Clin Invest. 2004;114:1414–1417
  18. Wang JJ, Qiao Q, Miettinen ME, et al. The metabolic syndrome defined by factor analysis and incident type 2 diabetes in Chinese population with high post-prandial glucose. Diabetes Care. 2004;27:2429–2437
  19. Wang JJ, Hu G, Lappalainen J, et al. Changes in features of the metabolic syndrome and incident impaired glucose regulation or type 2 diabetes in a Chinese population. Diabetes Care. 2005;28:448–450
  20. Gu D, Reynolds K, Duan X, et al. Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: international collaborative study of cardiovascular disease in Asia (InterASIA). Diabetologia. 2003;46:1190–1198
  21. Nomiyama T, Tanaka Y, Piao L, et al. Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients. Ann NYAS Online. 2004;1011:193–204
  22. Park SY, Choi GH, Choi HI, et al. Depletion of mitochondrial DNA causes impaired glucose utilization and insulin resistance in L6 GLUT4mycmyacytes. J Biol Chem. 2005;280:9855–9864
  23. Vasudevan DM, Sreekumari S. Textbook of biochemistry. India: Jaypee Brothers’ Medical Publishers (P) Ltd.; 2005;p. 371–8
  24. Tessa A, Giannotti A, Tieri L, et al. Maternally inherited deafness associated with a T1095C mutation in the mDNA. Eur J Hum Genet. 2001;9(2):147–149
  25. Tamagawa Y, Kitamura K, Hagiwara H, et al. Audiologic findings in patients with a point mutation at nucleotide 3243 of mitochondrial DNA. Ann Otol Rhinol Laryngol. 1997;106(4):338–342
  26. Kaltzis V, Petit C. The fundamental and medical impacts of recent progress in research on hereditary hearing loss. Human Mol Genet. 1998;7:1589–1597
  27. Ji L, Hou X, Han X. Prevalence and clinical characteristics of mitochondrial tRNAleu(UUR) nt 3243 A–G and nt 3316 G–A mutations in Chinese patients with type 2 diabetes. Diabetes Res Clin Pract. 2001;54(2):35–38

PII: S1877-5934(09)00003-4

doi: 10.1016/j.ijdm.2009.03.012

International Journal of Diabetes Mellitus
Volume 1, Issue 1 , Pages 11-15 , April 2009

Article Tools

* Image Usage & Resolution