Influence of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in animal models
Received 20 July 2009; accepted 5 October 2009. published online 13 November 2009.
Abstract
Background
The objective of this study was to investigate the effect of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination.
Methods
Blood samples were analysed for blood glucose by GOD/POD method, serum gliclazide levels by HPLC method and insulin by Radio Immuno Assay method.
Results
In combination, atazanavir significantly enhanced the pharmacodynamic activity and altered the pharmacokinetic parameters of gliclazide in animal models.
Conclusions
The interaction between atazanavir and gliclazide appears to be pharmacokinetic interaction at metabolic level in animal models.
ABSTRACT