International Journal of Diabetes Mellitus
Volume 2, Issue 1 , Pages 56-60, April 2010

Influence of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in animal models

  • S.K. Mastan

      Affiliations

    • Research Scholar, Jawaharlal Nehru Technological University, Hyderabad 500 072, Andhra Pradesh, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 891 2733737; fax: +91 891 2525611.
    • ,
  • K. Eswar Kumar

      Affiliations

    • Pharmacology Division, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India

Received 20 July 2009; accepted 5 October 2009. published online 13 November 2009.

Abstract 

Background

The objective of this study was to investigate the effect of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination.

Methods

Blood samples were analysed for blood glucose by GOD/POD method, serum gliclazide levels by HPLC method and insulin by Radio Immuno Assay method.

Results

In combination, atazanavir significantly enhanced the pharmacodynamic activity and altered the pharmacokinetic parameters of gliclazide in animal models.

Conclusions

The interaction between atazanavir and gliclazide appears to be pharmacokinetic interaction at metabolic level in animal models.

Keywords: Gliclazide, Atazanavir, Diabetes, HIV infection, Hypoglycemia, Pharmacokinetics

 

PII: S1877-5934(09)00053-8

doi:10.1016/j.ijdm.2009.10.001

International Journal of Diabetes Mellitus
Volume 2, Issue 1 , Pages 56-60, April 2010

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