Volume 2, Issue 1 , Pages 32-37, April 2010
Dietary fiber psyllium based hydrogels for use in insulin delivery
Abstract
The present article is related to the development of psyllium based oral insulin delivery systems that could release insulin in a controlled and sustained manner. Psyllium is a medicinally important gel, forming glucose lowering dietary fiber and drug delivery system developed by its functionalization will have the double potential of curing diabetes. Psyllium and acrylamide/methacrylamide based hydrogels were prepared, and the effect of pH on the release dynamics of insulin from drug loaded hydrogels has been studied to evaluate the drug release mechanism. Non-Fickian diffusion mechanism has been observed for the release of insulin in the pH 7.4 buffer.
Keywords: Drug delivery devices, Hydrogels, Insulin, Diabetes mellitus
PII: S1877-5934(09)00071-X
doi:10.1016/j.ijdm.2009.12.014
© 2009 International Journal of Diabetes Mellitus. Published by Elsevier Inc. All rights reserved.
Volume 2, Issue 1 , Pages 32-37, April 2010
