International Journal of Diabetes Mellitus
Volume 2, Issue 2 , Pages 114-118, August 2010

T-cell protein tyrosine phosphatase: A role in inflammation and autoimmunity

  • Dimitry A. Chistiakov

      Affiliations

    • Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 113545 Moscow, Russia
    • Corresponding Author InformationCorresponding author. Address: Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 1st Dorozhny Proezd 1, 117545 Moscow, Russia. Tel.: +7 (495) 3150265; fax: +7 (495) 3150501.
    • ,
  • Emma I. Chistiakova

      Affiliations

    • Department of Diabetology, Endocrinological Research Center, 117036 Moscow, Russia

Received 7 February 2010; received in revised form 23 May 2010; accepted 24 May 2010. published online 16 June 2010.

Abstract 

A cDNA of PTPN2 encoding for T-cell protein tyrosine phosphate (TC-PTP) was isolated and characterized as long as 20years ago. However, findings suggesting a potentially exciting role of this enzyme in general autoimmunity have only recently been obtained. Genome-wide association scans of the human genome revealed the involvement of PTPN2 in susceptibility to a several autoimmune disorders such as Crohn’s disease, type 1 diabetes, and Graves’ disease. Functional studies in immune cells revealed a key role of this enzyme in down-regulation of cytokine expression and inflammatory response, which provides an essential background to explaining the pathophysiological role of TC-PTP in autoimmunity. Thus, in addition to PTPN22, PTPN2 is likely to represent a second member of the broad family of non-receptor PTPs contributing to general autoimmunity.

Keywords: Cytokine expression, General autoimmunity, Inflammation, PTPN22, Susceptibility, T-cell protein tyrosine phosphate

 

PII: S1877-5934(10)00034-2

doi:10.1016/j.ijdm.2010.05.012

International Journal of Diabetes Mellitus
Volume 2, Issue 2 , Pages 114-118, August 2010

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